Substance / Medication

Chlorhexidine

SNOMED 373568007 UMLS C0008196

Overview

Active Ingredient

chlorhexidine

RxNorm CUI

2358

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Periodontal disease

Candidiasis of mouth

Infection of skin

Disease caused by Gram-negative bacteria

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

29 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Staph Household Intervention for Eradication (SHINE)

NCT02572791Phase 4Completed835 enrolled

Chlorhexidine Lavage for Recurrent Urinary Tract Infection

NCT06598514Phase 4Active Not Recruiting136 enrolled

Protocol Efficacy of Mouthwashes in Experimental Gingivitis

NCT07270952Phase 4Completed34 enrolled

Sore Throat After Open Neck Elective Surgery

NCT07124650Phase 4Recruiting764 enrolled

Animal-Assisted Visitation Program Chlorhexidine Trial

NCT04171817Phase 4Completed45 enrolled

View all 29 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Chlorhexidine is the preferred agent for vaginal antisepsis prior to cesarean delivery: a systematic review and network meta-analysis.

McKinney Jordan A, Sanchez-Ramos Luis, Duncan Jose et al. · Am J Obstet Gynecol · 2026

PMID: 41485838Meta-Analysis

Chlorhexidine Compared with Povidone-Iodine in Intravitreal Injection: A Systematic Review and Meta-Analysis.

Cruz Matheus Ribeiro Barbosa, Amaral Dillan Cunha, Gonçalves Ocílio Ribeiro et al. · J Ocul Pharmacol Ther · 2025

PMID: 39836046Meta-Analysis

A comparative meta-analysis of povidone-iodine-alcohol vs. chlorhexidine-alcohol for preoperative skin antisepsis in abdominal surgery.

Hsieh Hua-Hsin, Yu Yueh, Chang Che-Jui et al. · Am J Surg · 2025

PMID: 40188587Meta-Analysis

Glutaraldehyde, Chlorhexidine, and Peracetic Acid are Preferred Disinfectants for Repeated or Prolonged Disinfection of Denture Base Resins.

Komlenic Vojislav, Puzovic Katarina, Beljic-Ivanovic Katarina et al. · J Evid Based Dent Pract · 2025

PMID: 41290280Meta-Analysis

Chlorhexidine versus povidone-iodine for surgical site infection prevention: an updated meta-analysis and trial sequential analysis of randomized controlled trials.

Yang Shengyi, Li Zhenwei, Wu Feiyu et al. · Front Med (Lausanne) · 2025

PMID: 41357507Meta-AnalysisFull text (PMC)

Chlorhexidine or Povidone-Iodine Solution Irrigation Versus Saline Irrigation for the Prevention of Postoperative Infections in Primary Total Joint Arthroplasty: A Systematic Review and Meta-Analysis.

Machinski Elcio, da Cruz Vinícius F, Conde Rodrigo A S et al. · J Arthroplasty · 2025

PMID: 39971205Meta-Analysis

Effect of Different Concentrations of Chlorhexidine on Anti-Plaque in Oral Care Practice: A Systematic Review and Network Meta-Analysis.

Liang Shiqi, He Yirong, Chen Xinrong et al. · Int J Dent Hyg · 2025

PMID: 39529177Meta-Analysis

Chlorhexidine solutions are more effective than povidone-iodine solutions as skin disinfectants for the prevention of intravascular catheter-related infections: A meta-analysis.

Deng Aiping, Xiong Fangli, Ren Qiuping · Sci Rep · 2025

PMID: 40148400Meta-AnalysisFull text (PMC)

The Effect of Cetylpyridinium Chloride Compared to Chlorhexidine Mouthwash on Scores of Plaque and Gingivitis: A Systematic Review and Meta-Analyses.

Windhorst Emmy Rowan, Joosstens Maud, van der Sluijs Eveline et al. · Int J Dent Hyg · 2025

PMID: 40530503Meta-AnalysisFull text (PMC)

The effect of oil pulling in comparison with chlorhexidine and other mouthwash interventions in promoting oral health: A systematic review and meta-analysis.

Jong Freda Jia Xin, Ooi Der Jiun, Teoh Siew Li · Int J Dent Hyg · 2024

PMID: 37635453Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Chlorhexidine (substance)
SNOMED CT: 373568007
UMLS CUI: C0008196
RxNorm CUI: 2358

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.