Substance / Medication

Chloroquine

Overview

Active Ingredient
chloroquine
RxNorm CUI
2393

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

26 trials linked to this intervention

26
Total Trials
3
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Chloroquine-resistant Plasmodium vivax malaria in Ethiopia: A systematic review and meta-analysis.
Wondmagegn Yenesew Mihret, Setegn Abebaw, Girmay Getu et al. · Acta Trop · 2026
PMID: 41407277Meta-Analysis
Prevalence of molecular markers of chloroquine resistance in malaria parasites in East Africa: A systematic review and meta-analysis.
Abebe Wagaw, Mekuanint Amare, Asmare Zelalem et al. · J Glob Antimicrob Resist · 2025
PMID: 39725320Meta-Analysis
Enhancing radiation sensitivity in malignant brain tumors with chloroquine: a systematic review.
Harary Paul M, Hori Yusuke S, Annagiri Shreyas et al. · J Neurooncol · 2025
PMID: 41348255Meta-Analysis
Hydroxychloroquine-Chloroquine, QT-Prolongation, and Major Adverse Cardiac Events: A Meta-analysis and Scoping Review.
Garcia Michael Cristian, Tsang Kai La, Lohit Simran et al. · Ann Pharmacother · 2024
PMID: 37881891Meta-AnalysisFull text (PMC)
Systematic Review of Psychiatric Adverse Effects Induced by Chloroquine and Hydroxychloroquine: Case Reports and Population Studies.
Talarico Fernanda, Chakravarty Sucheta, Liu Yang S et al. · Ann Pharmacother · 2023
PMID: 35927939Meta-Analysis
Hydroxychloroquine/chloroquine for the treatment of hospitalized patients with COVID-19: An individual participant data meta-analysis.
Di Stefano Leon, Ogburn Elizabeth L, Ram Malathi et al. · PLoS One · 2022
PMID: 36173983Meta-AnalysisFull text (PMC)
Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.
Kashour Zakariya, Riaz Muhammad, Garbati Musa A et al. · J Antimicrob Chemother · 2021
PMID: 33031488Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Chloroquine (substance)
SNOMED CT
373468005
UMLS CUI
C0008269
RxNorm CUI
2393

Clinical Data

This intervention maps to 15 entities in the Ltrl knowledge graph.

10
Conditions
2
Biomarkers
1
Specialists
0
Symptoms
26
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.