Substance / Medication

Cholic acid

Overview

Active Ingredient
cholic acid
RxNorm CUI
1440856
Labeler: Mirum Pharmaceuticals Inc.Updated: 2026-01-26T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
The clinical and biochemical effectiveness and safety of cholic acid treatment for bile acid synthesis defects: a systematic review.
Polak Yasmin, van Dussen Laura, Kemper E Marleen et al. · Orphanet J Rare Dis · 2024
PMID: 39702264Meta-AnalysisFull text (PMC)
Cholic acid for hepatic steatosis in patients with lipodystrophy: a randomized, controlled trial.
Ahmad Zahid, Subramanyam Lalitha, Szczepaniak Lidia et al. · Eur J Endocrinol · 2013
PMID: 23447519RCTFull text (PMC)
Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis.
Heubi James E, Setchell Kenneth D R · J Pediatr Gastroenterol Nutr · 2020
PMID: 31899729Trial
Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders.
Heubi James E, Bove Kevin E, Setchell Kenneth D R · J Pediatr Gastroenterol Nutr · 2017
PMID: 28644367TrialFull text (PMC)
Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy.
Gonzales Emmanuel, Gerhardt Marie F, Fabre Monique et al. · Gastroenterology · 2009
PMID: 19622360Trial
Plasma 14C-cholic acid clearance in healthy dogs and dogs with cholestasis or a congenital portosystemic shunt.
Bosje J T, Bunch S E, van den Brom W et al. · Vet Rec · 2005
PMID: 16040943Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cholic acid (substance)
SNOMED CT
17147002
UMLS CUI
C0055568
RxNorm CUI
1440856
Labeler
Mirum Pharmaceuticals Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.