Substance / Medication

Clobetasol

SNOMED 419129004 UMLS C0008992

Overview

Active Ingredient

clobetasol

RxNorm CUI

2590

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Dermatosis of scalp

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

12 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo

NCT07398807EARLY_Phase 1Recruiting40 enrolled

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

NCT04207931Phase 4Recruiting250 enrolled

Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus

NCT04951206Phase 4Completed212 enrolled

Anti-Inflammatory Effects of 0.045% Tazarotene/0.01% Halobetasol Lotion in Psoriasis

NCT06042647Phase 4Completed10 enrolled

A Comparison Between Clobetasol Propionate 0.05% (Clobex®) Spray and Clobetasol Propionate 0.05% (Olux®) Foam

NCT00436540Phase 4Completed78 enrolled

View all 12 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Efficacy and safety of topical clobetasol propionate in comparison with alternative treatments in oral lichen planus: an updated systematic review and meta-analysis.

Zheng Tao, Liu ChengYong, Wang YeTong et al. · Front Med (Lausanne) · 2024

PMID: 38854667Meta-AnalysisFull text (PMC)

Allergens in Common Brands of Clobetasol.

Ramani Leena, Haidari Wasim, Hall Shalanda et al. · J Drugs Dermatol · 2023

PMID: 37133477Meta-Analysis

Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations.

Feldman Steven R, Yentzer Brad A · Am J Clin Dermatol · 2009

PMID: 19824740Meta-Analysis

Evaluation of the efficacy of supplementary probiotic capsules with topical clobetasol propionate 0.05% versus topical clobetasol propionate 0.05% in the treatment of oral lichen planus (a randomized clinical trial).

Kamal Yasmine, Abdelwhab Amira, Salem Sherifa Tarek et al. · BMC Oral Health · 2025

PMID: 40045332RCTFull text (PMC)

Time-Dependent Changes in Salivary Antioxidants After 5-ALA Photodynamic Therapy vs. Clobetasol in Oral Lichen Planus: A Randomized Clinical Trial.

Wiśniewski Patryk, Sulewska Magdalena, Tomaszuk Jagoda et al. · Int J Mol Sci · 2025

PMID: 41303714RCTFull text (PMC)

Comparative evaluation of the efficacy of Nigella sativa (75% v/v) cream and clobetasol propionate (0.05% w/w) gel in oral lichen planus-a double-blinded randomized control trial.

Kumar S Lokesh, Naik Zameera, Panwar Arun et al. · Oral Maxillofac Surg · 2024

PMID: 36547822RCT

Comparative evaluation of the efficacy of topical tacrolimus 0.03% and topical calcipotriol 0.005% mixed with betamethasone dipropionate versus topical clobetasol 0.05% in treatment of alopecia areata: A clinical and trichoscopic study.

Nassar Amany, Elradi Mona, Radwan Mona et al. · J Cosmet Dermatol · 2023

PMID: 36575890RCT

Randomized clinical trial with fractional COlaser and Clobetasol in the treatment of Vulvar Lichen Sclerosus: a clinic study of feasibility.

Salgado Hakayna Calegaro, Drumond Denise Gasparetti, Pannain Gabriel Duque et al. · BMC Res Notes · 2023

PMID: 36894959RCTFull text (PMC)

Efficacy of the topical cyclosporine cream assisted by fractional carbon dioxide laser vs topical clobetasol cream for the treatment of plaque psoriasis: Randomized comparative study.

Helmy A Yasser, El Batreek Mohamed Hashem, Abdel Fadeel Doaa Ahmed et al. · J Cosmet Dermatol · 2022

PMID: 34791789RCT

Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: a randomized controlled trial.

Mahmoudi Hamidreza, Rostami Anahita, Tavakolpour Soheil et al. · J Dermatolog Treat · 2022

PMID: 32238014RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Clobetasol (substance)
SNOMED CT: 419129004
UMLS CUI: C0008992
RxNorm CUI: 2590

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.