Substance / Medication

dl-alpha-tocopherol

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Alzheimer's disease

Vitamin E deficiency

Hemolytic anemia

Drug-induced dyskinesia

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol.

Foote Janet A, Ranger-Moore James R, Einspahr Janine G et al. · Cancer Prev Res (Phila) · 2009

PMID: 19336724RCTFull text (PMC)

DL-alpha-tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice.

Sakamoto Natsumi, Ozawa Manabu, Yokotani-Tomita Kaori et al. · Reproduction · 2008

PMID: 18367509Observational

Testing the Effects of DL-Alpha-Tocopherol Supplementation on Oxidative Damage, Total Antioxidant Protection and the Sex-Specific Responses of Reproductive Effort and Lifespan to Dietary Manipulation in Australian Field Crickets (Teleogryllus commodus).

Archer C Ruth, Hempenstall Sarah, Royle Nick J et al. · Antioxidants (Basel) · 2015

PMID: 26783958OtherFull text (PMC)

Glycosidic moiety changes the spectroscopic properties of dl-alpha-tocopherol in DMSO/water solution and in organic solvents.

Neunert G, Polewski P, Walejko P et al. · Spectrochim Acta A Mol Biomol Spectrosc · 2009

PMID: 19346158Other

Age and gender-related reference values for serum dl-alpha-tocopherol and all-trans-retinol levels in Saudi population.

Al-Saleh Iman, El-Doush Inaam, Billedo Grisellhi · Int J Vitam Nutr Res · 2007

PMID: 18453317Other

[Determination of dl-alpha-tocopherol acetate and dl-alpha-tocopherol in foods by HPLC using post-column photochemical reaction].

Terada Hisaya, Tamura Yukio · Shokuhin Eiseigaku Zasshi · 2004

PMID: 15794085Other

Influence of DL-alpha-tocopherol acetate on indomethacin-induced gastric mucosal injury in rats.

Valcheva-Kuzmanova S, Krasnaliev I, Galunska B et al. · Auton Autacoid Pharmacol · 2007

PMID: 17584442Preclinical

Protective effects of ascorbic acid, dl-alpha-tocopherol acetate, and sodium selenate on ethanol-induced liver damage of rats.

Ozdil Sadakat, Bolkent Sehnaz, Yanardag Refiye et al. · Biol Trace Elem Res · 2004

PMID: 14985625Preclinical

Protective effects of ascorbic acid, DL-alpha-tocopherol acetate, and sodium selenate on ethanol-induced gastric mucosal injury of rats.

Ozdil Sadakat, Yanardag Refiye, Koyuturk Meral et al. · Biol Trace Elem Res · 2004

PMID: 15235151Preclinical

Reduction of ischemia-reperfusion injury in parenchymal and nonparenchymal liver cells by donor treatment with DL-alpha-tocopherol prior to organ harvest.

Gondolesi G E, Lausada N, Schinella G et al. · Transplant Proc · 2002

PMID: 12072284Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: dl-alpha-tocopherol (substance)
SNOMED CT: 812121000168101
UMLS CUI: C1323100

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.