Substance / Medication

Donepezil

Overview

Active Ingredient
donepezil
RxNorm CUI
135447

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

40 trials linked to this intervention

40
Total Trials
1
Recruiting
19
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Donepezil for cancer-related cognitive impairment: systematic review and meta-analysis.
Fornalik Michał, Moska Sandra, Gimła Mariola et al. · Clin Exp Med · 2025
PMID: 40495003Meta-AnalysisFull text (PMC)
Effectiveness of acupuncture combined with donepezil for Alzheimer's disease: A systematic review and meta-analysis.
Wu Yue, Zhan Yijun, Zhu Wenyan et al. · Medicine (Baltimore) · 2025
PMID: 40489837Meta-AnalysisFull text (PMC)
Butylphthalide combined with donepezil for the treatment of vascular dementia: a meta-analysis.
Liu Puqing, Liu Xiangjuan, Chen Jingwen et al. · J Int Med Res · 2024
PMID: 38546241Meta-AnalysisFull text (PMC)
Oral Chinese herbal medicine combined with donepezil for mild cognitive impairment: A systematic review and meta-analysis.
Liu Lingling, Zhang Claire Shuiqing, Zhang Anthony Lin et al. · J Am Geriatr Soc · 2024
PMID: 39134455Meta-AnalysisFull text (PMC)
Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta-analysis.
Nham Tina, Garcia Michael Cristian, Tsang Kai La Jennifer et al. · J Am Geriatr Soc · 2024
PMID: 38580328Meta-Analysis
The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis.
Hsieh Cheng-Fang, Tseng Ping-Tao, Chen Tien-Yu et al. · J Formos Med Assoc · 2022
PMID: 34753629Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Donepezil (substance)
SNOMED CT
386855006
UMLS CUI
C0527316
RxNorm CUI
135447

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
40
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.