Substance / Medication

Doxycycline hyclate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

RMSF - Rocky Mountain spotted fever

Anthrax

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

22 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Trachoma Elimination Follow-up

NCT00221364Phase 4Completed20000 enrolled

Trachoma Amelioration in Northern Amhara (TANA)

NCT00322972Phase 4Completed33000 enrolled

Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania

NCT00347607Phase 4Completed2700 enrolled

Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania

NCT00347763Phase 4Completed350 enrolled

Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger

NCT00348478Phase 4Completed720 enrolled

View all 22 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Comparative evaluation of demineralized freeze-dried bone allograft with and without doxycycline hyclate loaded proniosomal gel in the treatment of class II furcation defects: a randomized controlled trial.

Biradar Vaishnavi, Mody Dhawal, Kolte Abhay P et al. · Clin Oral Investig · 2025

PMID: 41114850RCT

Pharmacokinetics of an oral extended-release formulation of doxycycline hyclate containing acrylic acid and polymethacrylate in dogs.

Ruiz Sara Melisa Arciniegas, Olvera Lilia Gutiérrez, Chacón Sara del Carmen Caballero et al. · Am J Vet Res · 2015

PMID: 25815578RCT

Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis.

Vijayabala G Sree, Kalappanavar Anupama N, Annigeri Rajeshwari G et al. · Oral Surg Oral Med Oral Pathol Oral Radiol · 2013

PMID: 24035110RCT

Experimental determination of a subantimicrobial dosage of doxycycline hyclate for treatment of periodontitis in Beagles.

Kim Se Eun, Kim Soohee, Jeong Manbok et al. · Am J Vet Res · 2013

PMID: 23270357RCT

Comparative evaluation of the efficacy of 10% doxycycline hyclate in the periodontal treatment of smokers - a clinical and microbiological study.

Sandhya Y P, Prabhuji M L, Chandra Rampalli Viswa · Oral Health Prev Dent · 2011

PMID: 21594208RCT

Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis.

Gupta Rajan, Pandit Nymphea, Aggarwal Shweta et al. · J Contemp Dent Pract · 2008

PMID: 18997913RCT

A randomized, double-blind, placebo-controlled trial of the combined effect of doxycycline hyclate 20-mg tablets and metronidazole 0.75% topical lotion in the treatment of rosacea.

Sanchez Jorge, Somolinos Aida Lugo, Almodóvar Pablo I et al. · J Am Acad Dermatol · 2005

PMID: 16243127RCT

Comparative pharmacokinetics of a new oral long-acting formulation of doxycycline hyclate: A canine clinical trial.

Arciniegas Ruiz Sara Melisa, Gutiérrez Olvera Lilia, Bernad Bernad María Josefa et al. · Eur J Pharm Sci · 2015

PMID: 26393684Observational

The use of controlled release locally delivered 10% doxycycline hyclate gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: clinical and microbiological results.

Ahamed Shabeer, Jalaluddin Md, Khalid Imran et al. · J Contemp Dent Pract · 2013

PMID: 24858755Observational

Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg.

Gold Linda Stein, Cruz Alma, Eichenfield Lawrence et al. · Cutis · 2010

PMID: 20349684Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Doxycycline hyclate (substance)
SNOMED CT: 71417000
UMLS CUI: C0058731

Clinical Data

This intervention maps to 12 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.