Substance / Medication

Etomidate

Overview

Active Ingredient
etomidate
RxNorm CUI
4177

Indications

CLINICAL PHARMACOLOGY ADVERSE REACTIONS Etomidate Injection USP is indicated by intravenous injection for the induction of general anesthesia. When considering use of etomidate, the usefulness of its hemodynamic properties (see) should be weighed against the high frequency of transient skeletal muscle movements (see). Intravenous etomidate is also indicated for the supplementation of subpotent anesthetic agents, such as nitrous oxide in oxygen, during maintenance of anesthesia for short operativ

Labeler: Caplin Steriles LimitedUpdated: 2026-02-05T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Etomidate is contraindicated in patients who have shown hypersensitivity to it.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

7
Total Trials
3
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Readdressing rapid sequence induction and intubation using ketamine or etomidate: A systematic review and meta-analysis of randomized clinical trials.
de Morais Lucas Bittar, Radel-Neto Guilherme Requião, Dos Santos Valsecchi Victor Alexandre et al. · Medicine (Baltimore) · 2025
PMID: 40355221Meta-AnalysisFull text (PMC)
Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials.
Greer Alisha, Hewitt Mark, Khazaneh Parsa T et al. · Crit Care Med · 2025
PMID: 39570063Meta-Analysis
Etomidate versus ketamine for in-hospital rapid sequence intubation: a systematic review and meta-analysis.
Daghmouri Mohamed Aziz, Chaouch Mohamed Ali, Noomen Mohamed et al. · Eur J Emerg Med · 2025
PMID: 40239104Meta-Analysis
Etomidate vs Ketamine-Propofol for Induction of Anesthesia in Coronary Artery Bypass Grafting: An Updated Systematic Review and Meta-Analysis.
Kumar Nicolas, Bardia Amit, Fitzsimons Michael G et al. · Semin Cardiothorac Vasc Anesth · 2025
PMID: 40221834Meta-Analysis
Authors response: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".
Kotani Yuki, Piersanti Gioia, Maiucci Giacomo et al. · J Crit Care · 2024
PMID: 37690923Meta-Analysis
Letter to the editor: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".
Horst Karen Utz, do Rosário Mariana Berger, Rech Tatiana Helena · J Crit Care · 2024
PMID: 37689563Meta-Analysis
Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis.
Koroki Takatoshi, Kotani Yuki, Yaguchi Takahiko et al. · Crit Care · 2024
PMID: 38368326Meta-AnalysisFull text (PMC)
Authors response: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".
Kotani Yuki, Semler Matthew W, Lee Todd C et al. · J Crit Care · 2024
PMID: 37690922Meta-Analysis
Letter to the editor: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".
Lavin Cassidy, Tran Quincy K, Downing Jessica et al. · J Crit Care · 2024
PMID: 37703745Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Etomidate (substance)
SNOMED CT
387218008
UMLS CUI
C0015131
RxNorm CUI
4177
Labeler
Caplin Steriles Limited

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.