Substance / Medication

Factor I

Overview

Active Ingredient
fibrinogen
RxNorm CUI
4385

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Pathogenic Mechanisms in Congenital Afibrinogenemia: A Systematic Review of Genetic Variants.
Li Yang, Meng Zirui, Qing Wei et al. · Haemophilia · 2025
PMID: 40099427Meta-Analysis
Point-of-care testing for diagnosing hypofibrinogenemia in postpartum hemorrhage: Systematic review and meta-analysis.
Nakamura Eishin, Mihara Takahiro, Kondo Yuriko et al. · Thromb Res · 2025
PMID: 40378705Meta-Analysis
Congenital (hypo-)dysfibrinogenemia and bleeding: A systematic literature review.
Li Yang, Ding Biying, Wang Xuefeng et al. · Thromb Res · 2022
PMID: 35853369Meta-Analysis
Diagnostic accuracy of viscoelastic point-of-care identification of hypofibrinogenaemia in cardiac surgical patients: A systematic review.
Gibbs Neville M, Weightman William M · Anaesth Intensive Care · 2020
PMID: 33016097Meta-Analysis
Obstetrical and postpartum complications in women with hereditary fibrinogen disorders: A systematic literature review.
Valiton Vivian, Hugon-Rodin Justine, Fontana Pierre et al. · Haemophilia · 2019
PMID: 31368232Meta-Analysis
Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review.
Nagler Michael, Kremer Hovinga Johanna A, Alberio Lorenzo et al. · Thromb Haemost · 2016
PMID: 27384135Meta-Analysis
Prospective, Randomized Study of Fibrinogen Concentrate Versus Cryoprecipitate for Correcting Hypofibrinogenemia in Cardiac Surgery Patients.
Ayaganov Dauren, Kuanyshbek Aidyn, Vakhrushev Ivan et al. · J Cardiothorac Vasc Anesth · 2024
PMID: 38016817RCT
Practice patterns of ABO-matching for cryoprecipitate and patient outcomes after ABO-compatible versus incompatible cryoprecipitate.
Raycraft Tyler, Bartoszko Justyna, Karkouti Keyvan et al. · Vox Sang · 2022
PMID: 35791670RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Factor I (substance)
SNOMED CT
259790000
UMLS CUI
C0016006
RxNorm CUI
4385

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Factor I — Conditions, Biomarkers & Specialists | Ltrl | Ltrl