Substance / Medication

Fluorouracil

Overview

Active Ingredient
fluorouracil
RxNorm CUI
4492

Indications

Fluorouracil is indicated for the treatment of patients with:

Labeler: Xiromed LLCUpdated: 2026-02-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

61 trials linked to this intervention

61
Total Trials
26
Recruiting
9
With Results

Research Evidence

Published studies and systematic reviews

Sort:
5-Fluorouracil in Facial Plastic Surgery: Indications, Efficacy, and Safety - A Systematic Review and Narrative Synthesis.
Bogari Ahmad, Jomah Mohammed, Alshehri Naif et al. · Facial Plast Surg · 2026
PMID: 39965761Meta-Analysis
Exploring the use and efficacy of 5-fluorouracil in the management of odontogenic keratocysts: a systematic review and meta-analysis.
Mahmoud Reema, Kleinman Shlomi, Shuster Amir et al. · BMC Oral Health · 2025
PMID: 41454329Meta-Analysis
Effectiveness and Tolerability of Various 5-Fluorouracil Formulations as Adjuvant Therapies for Vitiligo Management: A Systematic Review and Meta-Analysis.
Kohaf Neveen A, Sarsik Sameh M, Salman Samar et al. · Curr Rev Clin Exp Pharmacol · 2025
PMID: 39428927Meta-Analysis
Treatment of Metastatic Biliary Cancers With Irinotecan and 5-Fluorouracil Based Chemotherapy After Platinum/Gemcitabine Progression: A Systematic Review and Meta-Analysis.
Voutsadakis Ioannis A, Kokkali Stefania, Digklia Antonia · Clin Colorectal Cancer · 2024
PMID: 38902137Meta-Analysis
Comparing 5-Fluorouracil Versus Modified Carnoy's Solution for the Treatment of Odontogenic Keratocysts: A Systematic Review and Meta-Analysis.
Jacobs Tyler, Patil Disha, Shanti Rabie et al. · J Oral Maxillofac Surg · 2024
PMID: 39038594Meta-Analysis
S-1 and 5-Fluorouracil-related adverse events in patients with advanced gastric cancer: A meta-analysis.
Hu Qingqing, Xu Jiajia, Ke Jingshu et al. · PLoS One · 2023
PMID: 37566608Meta-AnalysisFull text (PMC)
High vs. low-dose leucovorin in regimens with fluorouracil in colorectal cancer therapy.
Juřica Jan, Šuverová Pavlína, Goněc Roman et al. · Ceska Slov Farm · 2023
PMID: 37648426Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Fluorouracil (substance)
SNOMED CT
387172005
UMLS CUI
C0016360
RxNorm CUI
4492
Labeler
Xiromed LLC

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

8
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
61
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.