Substance / Medication

Gabapentin

Overview

Active Ingredient
gabapentin
RxNorm CUI
25480

Indications

Gabapentin is indicated for: Management of postherpetic neuralgia in adults Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization, in adults and pediatric patients 3 years and older with epilepsy

Labeler: PD-Rx Pharmaceuticals, Inc.Updated: 2026-02-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and Safety of Pregabalin and Gabapentin for Pruritus: A Systematic Review and Meta-Analysis.
Xu Wenting, Dong Hanyue, Ran Haolong et al. · J Pain Symptom Manage · 2025
PMID: 39173895Meta-Analysis
Evaluation of Carbamazepine and Gabapentin's Safety and Efficacy in Trigeminal Neuralgia Treatment: A Systematic Review and Meta-Analysis.
Yang Yan, Shang Haitao, Han Tao · Comb Chem High Throughput Screen · 2025
PMID: 39995139Meta-Analysis
Efficacy of prophylactic gabapentin in managing oral mucositis pain in patients undergoing non-surgical management of head and neck tumors.
Baig Virda, Hashmi Shehla F, Altuhafy Maryam et al. · Support Care Cancer · 2025
PMID: 40019561Meta-Analysis
Prophylactic efficacy of oral gabapentin on postoperative shivering: A meta-analysis of randomized controlled trials.
Liang Xiao, Chen Ming, Hong Aonan et al. · Medicine (Baltimore) · 2025
PMID: 40068032Meta-AnalysisFull text (PMC)
Cardiovascular safety of gabapentinoids gabapentin & pregabalin: A systematic review.
Dutta Deep, Mohindra Ritin, Kumar Manoj et al. · Indian J Med Res · 2025
PMID: 40536375Meta-AnalysisFull text (PMC)
Comparing Gabapentin and Pregabalin for Perioperative Pain Management in Lumbar Spine Surgery: A Systematic Review and Meta-Analysis.
Ebada Ali, Bever Nicholas, Carron Christopher J et al. · World Neurosurg · 2025
PMID: 40653011Meta-Analysis
Effects of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis.
Froehlich Katherine A, Deleon Zeus G, Tubog Tito D · J Perianesth Nurs · 2024
PMID: 37855760Meta-Analysis
Safety and Efficacy of Gabapentin for Pain in Pediatric Patients: A Systematic Review.
Branstetter Joshua W, Mantione Jill, Deangelo Alyssa et al. · Hosp Pediatr · 2024
PMID: 38098443Meta-Analysis
Risks of congenital malformations and neonatal intensive care unit admissions with gabapentin use in pregnancy: A cohort study and scoping review with meta-analysis.
Desrochers Brianne, Lavu Alekhya, Valencia Eunice et al. · Paediatr Perinat Epidemiol · 2024
PMID: 38773683Meta-Analysis
The efficacy of gabapentin supplementation for pain control after lumbar laminectomy and discectomy: A meta-analysis study.
Li Ruhui, Li Wenbin, Yao Xiongbin · Medicine (Baltimore) · 2024
PMID: 38905436Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Gabapentin (substance)
SNOMED CT
386845007
UMLS CUI
C0060926
RxNorm CUI
25480
Labeler
PD-Rx Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 11 entities in the Ltrl knowledge graph.

6
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.