Substance / Medication

Lacosamide

Overview

Active Ingredient
lacosamide
RxNorm CUI
623400
Labeler: Chartwell Governmental & Specialty RX, LLC.Updated: 2026-02-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

9 trials linked to this intervention

9
Total Trials
2
Recruiting
3
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy of adjunctive lacosamide in children with drug-resistant epilepsy: A systematic review, meta-analysis and meta-regression.
da Silva Anderson Matheus Pereira, de Deus Ocilio, Han Mariana Lee et al. · Seizure · 2025
PMID: 40911961Meta-Analysis
Efficacy and safety of lacosamide in pediatric patients with epilepsy: A systematic review and meta-analysis.
Yang Chunsong, Yang Yang, Peng Yuxuan et al. · Epilepsy Behav · 2022
PMID: 35914435Meta-Analysis
Clinical Efficacy and Safety of Lacosamide as an Adjunctive Treatment in Adults With Refractory Epilepsy.
Hou Liyan, Peng Bingjie, Zhang Defu et al. · Front Neurol · 2021
PMID: 34925202Meta-AnalysisFull text (PMC)
Lacosamide add-on therapy for focal epilepsy.
Babar Roshan K, Bresnahan Rebecca, Gillespie Conor S et al. · Cochrane Database Syst Rev · 2021
PMID: 33998660Meta-AnalysisFull text (PMC)
Efficacy of lacosamide and phenytoin in status epilepticus: A systematic review.
Panda Prateek Kumar, Panda Pragnya, Dawman Lesa et al. · Acta Neurol Scand · 2021
PMID: 33999428Meta-Analysis
The impact of lacosamide on mood disorders in adult patients with epilepsy: A systematic review.
Toniolo Sofia, Di Lorenzo Francesco, Bozzali Marco et al. · Epilepsy Behav · 2020
PMID: 32534419Meta-Analysis
Influence of adjunctive lacosamide in patients with seizures: a systematic review and meta-analysis.
Liu Hongju, Xu Xiaoli · Int J Neurosci · 2018
PMID: 29172828Meta-Analysis
Efficacy of lacosamide in children and adolescents with drug-resistant epilepsy and refractory status epilepticus: A systematic review.
Ortiz de la Rosa Johann Sebastián, Ladino Lady Diana, Rodríguez Paula Juliana et al. · Seizure · 2018
PMID: 29428899Meta-Analysis
Lacosamide in status epilepticus: Systematic review of current evidence.
Strzelczyk Adam, Zöllner Johann Philipp, Willems Laurent M et al. · Epilepsia · 2017
PMID: 28295226Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Lacosamide (substance)
SNOMED CT
441647003
UMLS CUI
C0893761
RxNorm CUI
623400
Labeler
Chartwell Governmental & Specialty RX, LLC.

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

4
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
9
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.