Substance / Medication

Nortriptyline

Overview

Active Ingredient
nortriptyline
RxNorm CUI
7531

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

11 trials linked to this intervention

11
Total Trials
3
Recruiting
5
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Quantitative analysis of nortriptyline's analgesic properties: a comparative systematic review and meta-analysis.
Hashemzadeh Soroush, Mortazavi Mohammad, Abdi Dezfouli Ramin · BMJ Open · 2024
PMID: 39122393Meta-AnalysisFull text (PMC)
Nortriptyline for neuropathic pain in adults.
Derry Sheena, Wiffen Philip J, Aldington Dominic et al. · Cochrane Database Syst Rev · 2015
PMID: 25569864Meta-AnalysisFull text (PMC)
Safety of nortriptyline at equivalent therapeutic doses for smoking cessation: a systematic review and meta-analysis.
Dhippayom Teerapon, Chaiyakunapruk Nathorn, Jongchansittho Thitima · Drug Saf · 2011
PMID: 21332244Meta-Analysis
Should nortriptyline be used as a first-line aid to help smokers quit? Results from a systematic review and meta-analysis.
Wagena E J, Knipschild P, Zeegers M P A · Addiction · 2005
PMID: 15733245Meta-Analysis
Optimal Dosing of Nortriptyline-Topiramate and Verapamil-Paroxetine Combinations in Tinnitus Treatment.
Lee Ella J, Tawk Karen, Gutiérrez Pérez Martha Lucía et al. · Laryngoscope · 2025
PMID: 40515518RCT
Efficacy of Nortriptyline-Topiramate and Verapamil-Paroxetine in Tinnitus Management: A Randomized Placebo-Controlled Trial.
Abouzari Mehdi, Tawk Karen, Kim Joshua K et al. · Otolaryngol Head Neck Surg · 2025
PMID: 39588680RCTFull text (PMC)
Effectiveness of Escitalopram and Nortriptyline on Depressive Symptoms in Parkinson's disease: the ADepT-PD RCT pilot.
Schrag Anette, Carroll Camille, Lewis Glyn et al. · Health Technol Assess · 2025
PMID: 41217862RCTFull text (PMC)
Optimizing Nortriptyline Dosing: A Comparison between Pharmacogenetics-Based, Phenotype-Based, and Standard Dosing.
Vos Cornelis F, Coenen Marieke J H, Ter Hark Sophie E et al. · Clin Pharmacokinet · 2025
PMID: 40413686RCTFull text (PMC)
Efficacy and safety of cytisine versus nortriptyline for smoking cessation: A multicentre, randomized, double-blinded and placebo-controlled trial.
Rungruanghiranya Suthat, Tulatamakit Sirapat, Chittawatanarat Kaweesak et al. · Respirology · 2024
PMID: 39004954RCT
Efficacy and safety of venlafaxine versus nortriptyline for the preventive treatment of migraine: A double-blind randomized clinical trial.
Roghani Mehrdad, Ghaedi Gholamhossein, Iranzadeh Saeid et al. · Clin Neurol Neurosurg · 2024
PMID: 38901375RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Nortriptyline (substance)
SNOMED CT
372652004
UMLS CUI
C0028420
RxNorm CUI
7531

Clinical Data

This intervention maps to 12 entities in the Healos knowledge graph.

4
Conditions
4
Biomarkers
2
Specialists
0
Symptoms
11
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.