Substance / Medication

Pentosan polysulfate sodium

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Ulcerative cystitis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Risk and Dose-Response Relationship for Pentosan Polysulfate Sodium Maculopathy: A Systematic Review and Meta-Analysis.

Tao Brendan K, Sawires Korolos, Lim Kate et al. · Ophthalmol Retina · 2025

PMID: 40074062Meta-Analysis

Efficacy of intravesical pentosan polysulfate sodium in cats with obstructive feline idiopathic cystitis.

Delille Mareike, Fröhlich Laura, Müller Ralf S et al. · J Feline Med Surg · 2016

PMID: 26116618RCTFull text (PMC)

Urinary epidermal growth factor and interleukin-6 levels in patients with painful bladder syndrome/interstitial cystitis treated with cyclosporine or pentosan polysulfate sodium.

Sairanen Jukka, Hotakainen Kristina, Tammela Teuvo L J et al. · Urology · 2008

PMID: 18387391RCT

Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial.

Davis Edward L, El Khoudary Samar R, Talbott Evelyn O et al. · J Urol · 2008

PMID: 18001798RCT

Potassium sensitivity test (PST) as a measurement of treatment efficacy of painful bladder syndrome/interstitial cystitis: a prospective study with cyclosporine A and pentosan polysulfate sodium.

Sairanen Jukka, Tammela Teuvo L J, Leppilahti Mikael et al. · Neurourol Urodyn · 2007

PMID: 17078084RCT

Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial.

Budsberg Steven C, Bergh Mary Sarah, Reynolds Lisa R et al. · Vet Surg · 2007

PMID: 17461948RCT

Pharmacokinetics and pharmacodynamics of warfarin when coadministered with pentosan polysulfate sodium.

Modi Nishit B, Kell Sherron, Simon Mary et al. · J Clin Pharmacol · 2005

PMID: 16027402RCT

Pentosan Polysulfate Sodium Exposure and Drug-Induced Maculopathy in Commercially Insured Patients in the United States.

Ludwig Cassie A, Vail Daniel, Callaway Natalia F et al. · Ophthalmology · 2020

PMID: 31899034Observational

Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: insights from a randomized, double-blind, placebo controlled study.

Nickel J Curtis, Herschorn Sender, Whitmore Kristene E et al. · J Urol · 2015

PMID: 25245489Observational

Time to initiation of pentosan polysulfate sodium treatment after interstitial cystitis diagnosis: effect on symptom improvement.

Nickel J Curtis, Kaufman David M, Zhang Huabin F et al. · Urology · 2008

PMID: 18242365Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Pentosan polysulfate sodium (substance)
SNOMED CT: 109117004
UMLS CUI: C0524684

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.