Substance / Medication

Piperazine

SNOMED 428714003 UMLS C0031957

Overview

Active Ingredient

piperazine

RxNorm CUI

8340

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Ascariasis

Nematode infection

Infection by Enterobius vermicularis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya

NCT02397772Phase 4Completed21761 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Improving renoprotective effects by adding piperazine ferulate and angiotensin receptor blocker in diabetic nephropathy: a meta-analysis of randomized controlled trials.

Yang Chiehlun, Yang Wenhsing, Chen Yenjen et al. · Int Urol Nephrol · 2022

PMID: 34191230Meta-Analysis

Therapeutic Efficacy of Piperazine Ferulate Combined With Irbesartan in Diabetic Nephropathy: A Systematic Review and Meta-analysis.

Li Dan, Li Bo, Peng Li-Xia et al. · Clin Ther · 2020

PMID: 33158581Meta-Analysis

Investigation of the effects of 'piperazine-containing party pills' and dexamphetamine on interhemispheric communication using electroencephalography.

Lee HeeSeung, Wang Grace Y, Curley Louise E et al. · Psychopharmacology (Berl) · 2016

PMID: 27289365RCT

Pharmacokinetic evaluation of a newly developed piperazine dithioctate formulation in healthy volunteers.

Zheng Renhua, Song Hyung Ho, Kwon Young Ee et al. · Int J Clin Pharmacol Ther · 2014

PMID: 25345429RCT

A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia.

Chota Amos, Sikasunge Chummy Sikalizyo, Phiri Andrew M et al. · Trop Anim Health Prod · 2010

PMID: 19701804RCT

Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children.

Rehman Hina, Naveed Safila, Usmanghani Khan · Pak J Pharm Sci · 2016

PMID: 27383495Trial

Development of LC/MS/MS assay for the determination of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one (SK3530) in human plasma: application to a clinical pharmacokinetic study.

Shin Beom Soo, Hu Seul Ki, Kim John et al. · J Pharm Biomed Anal · 2007

PMID: 17689219Trial

Treatment of type IIb familial combined hyperlipidemia with the combination pravastatin-piperazine sultosilate.

Masana Lluís, Villoria Jesús, Sust Mariano et al. · Eur J Pharmacol · 2004

PMID: 15288592Trial

Piperazine oestrone sulphate and interrupted norethisterone: effects on the postmenopausal endometrium.

Byrjalsen I, Alexandersen P, Christiansen C · BJOG · 2000

PMID: 10740331Trial

Piperazine oestrone sulphate and interrupted norethisterone in postmenopausal women: effects on bone mass, lipoprotein metabolism, climacteric symptoms, and adverse effects.

Alexandersen P, Byrjalsen I, Christiansen C · BJOG · 2000

PMID: 10740332Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Piperazine (substance)
SNOMED CT: 428714003
UMLS CUI: C0031957
RxNorm CUI: 8340

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.