Substance / Medication

Procyclidine

Overview

Active Ingredient
procyclidine
RxNorm CUI
8718

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.
Jevtovic-Todorovic V, Meyenburg A P, Olney J W et al. · Neuropharmacology · 2003
PMID: 12681372Observational
Rivastigmine for the treatment of anticholinergic delirium following severe procyclidine intoxication.
Van Kernebeek M W, Ghesquiere M, Vanderbruggen N et al. · Clin Toxicol (Phila) · 2021
PMID: 32960128Case Report
Case Series of Akathisia in Palliative Medicine: Patient Perspective and Efficacy of Procyclidine in Diagnosis and Management.
Murphy David, Maher Senan, Kennedy Grace et al. · Am J Hosp Palliat Care · 2025
PMID: 39352840OtherFull text (PMC)
Bioanalytical method for estimation of procyclidine in human plasma using liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study.
Bezawada Viritha, Mogili Padma, Dodda Sireesha et al. · Eur J Mass Spectrom (Chichester) · 2022
PMID: 35786035Other
Letter in response to Rivastigmine for the treatment of anticholinergic delirium following severe procyclidine intoxication.
Hughes Adrienne R, Moore Kerry K, Mah Nathan D et al. · Clin Toxicol (Phila) · 2021
PMID: 33576254Other
Pharmacokinetics of Double-Layer Patches With Microneedles Containing Procyclidine and Rivastigmine in Guinea Pigs.
Moon Minsun, Won Jihyun, Lee Yun-Woo et al. · Basic Clin Pharmacol Toxicol · 2025
PMID: 41118200PreclinicalFull text (PMC)
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Myhrer Trond, Mariussen Espen, Enger Siri et al. · Neurotoxicology · 2015
PMID: 26318504Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Procyclidine (substance)
SNOMED CT
387247001
UMLS CUI
C0033254
RxNorm CUI
8718

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.