Substance / Medication

Rofecoxib

Overview

Active Ingredient
rofecoxib
RxNorm CUI
232158

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Rofecoxib does not appear to increase the risk of venous thromboembolism: a systematic review of the literature.
Goy Jennifer, Paikin Jeremy, Crowther Mark · Thromb Res · 2014
PMID: 25246044Meta-Analysis
Single dose oral rofecoxib for acute postoperative pain in adults.
Bulley Simon, Derry Sheena, Moore R Andrew et al. · Cochrane Database Syst Rev · 2009
PMID: 19821329Meta-AnalysisFull text (PMC)
Single dose oral rofecoxib for postoperative pain.
Barden J, Edwards J, Moore R A et al. · Cochrane Database Syst Rev · 2005
PMID: 15674955Meta-Analysis
Rofecoxib for rheumatoid arthritis.
Garner S E, Fidan D D, Frankish R R et al. · Cochrane Database Syst Rev · 2005
PMID: 15674912Meta-AnalysisFull text (PMC)
Rofecoxib for osteoarthritis.
Garner S E, Fidan D D, Frankish R et al. · Cochrane Database Syst Rev · 2005
PMID: 15654705Meta-AnalysisFull text (PMC)
Single dose oral rofecoxib for postoperative pain.
Barden J, Edwards J, Moore R A et al. · Cochrane Database Syst Rev · 2004
PMID: 14974074Meta-Analysis
The upper gastrointestinal safety of rofecoxib vs. NSAIDs: an updated combined analysis.
Watson Douglas J, Yu Qinfen, Bolognese James A et al. · Curr Med Res Opin · 2004
PMID: 15462687Meta-Analysis
Rofecoxib for the treatment of rheumatoid arthritis.
Garner S, Fidan D, Frankish R et al. · Cochrane Database Syst Rev · 2002
PMID: 12137705Meta-Analysis
Rofecoxib for the treatment of rheumatoid arthritis.
Garner S, Fidan D, Frankish R et al. · Cochrane Database Syst Rev · 2002
PMID: 12076502Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Rofecoxib (substance)
SNOMED CT
387008005
UMLS CUI
C0762662
RxNorm CUI
232158

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.