Substance / Medication

Salicylate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

240 trials linked to this intervention

240
Total Trials
29
Recruiting
125
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Treatment with high dose salicylates improves cardiometabolic parameters: Meta-analysis of randomized controlled trials.
Baye Estifanos, Naderpoor Negar, Misso Marie et al. · Metabolism · 2017
PMID: 28521883Meta-Analysis
Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.
Juurlink David N, Gosselin Sophie, Kielstein Jan T et al. · Ann Emerg Med · 2015
PMID: 25986310Meta-Analysis
Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults.
Derry Sheena, Matthews Paul R L, Wiffen Philip J et al. · Cochrane Database Syst Rev · 2014
PMID: 25425092Meta-AnalysisFull text (PMC)
A meta-analysis of salicylates for type 2 diabetes mellitus.
Fang Fang, Lu Yu, Ma De-Lin et al. · J Huazhong Univ Sci Technolog Med Sci · 2013
PMID: 23392700Meta-Analysis
A systematic review of salicylates in foods: estimated daily intake of a Scottish population.
Wood Adrian, Baxter Gwen, Thies Frank et al. · Mol Nutr Food Res · 2011
PMID: 21351247Meta-Analysis
Salicylate for the treatment of Kawasaki disease in children.
Baumer J H, Love S J L, Gupta A et al. · Cochrane Database Syst Rev · 2006
PMID: 17054199Meta-AnalysisFull text (PMC)
Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain.
Mason Lorna, Moore R Andrew, Edwards Jayne E et al. · BMJ · 2004
PMID: 15033879Meta-AnalysisFull text (PMC)
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.
Cal Karina, Leyva Alejandro, Rodríguez-Duarte Jorge et al. · Nat Metab · 2025
PMID: 40527924RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Salicylate (substance)
SNOMED CT
255637000
UMLS CUI
C0036075

Clinical Data

This intervention maps to 6 entities in the Ltrl knowledge graph.

6
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
240
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.