Substance / Medication

Silybum marianum extract

Overview

Active Ingredient
milk thistle extract
RxNorm CUI
283579

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
1
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial.
Saberi Zohreh, Gorji Narjes, Memariani Zahra et al. · Phytother Res · 2020
PMID: 32762030RCT
Pressurized water versus ethanol as a Silybum marianum extraction solvent for inhibition of low-density lipoprotein oxidation mediated by copper and J774 macrophage cells.
Wallace Sunny N, Raible Jennifer, Carrier Danielle Julie et al. · Can J Physiol Pharmacol · 2007
PMID: 18066135Observational
Prediction of Permeation and Cellular Transport of Silybum marianum Extract Formulated in a Nanoemulsion by Using PAMPA and Caco-2 Cell Models.
Piazzini Vieri, Rosseti Chiara, Bigagli Elisabetta et al. · Planta Med · 2017
PMID: 28472840Other
The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats.
El Mesallamy Hala O, Metwally Nadia S, Soliman Mahmoud S et al. · Cancer Cell Int · 2011
PMID: 22040519OtherFull text (PMC)
Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
Boira Cloe, Chapuis Emilie, Lapierre Laura et al. · J Cosmet Dermatol · 2025
PMID: 39692756TrialFull text (PMC)
A study on the protective effect of Silybum marianum extract on hepatic ischemia-reperfusion injury.
Liu Shaojun, Chen Zhiheng, Cao Dongbo et al. · Afr J Tradit Complement Altern Med · 2013
PMID: 24311841PreclinicalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Silybum marianum extract (substance)
SNOMED CT
412434008
UMLS CUI
C0937640
RxNorm CUI
283579

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.