Substance / Medication

Topotecan hydrochloride

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma.
Paez-Escamilla Manuel, Bagheri Nika, Teira Laila E et al. · JAMA Ophthalmol · 2017
PMID: 29098282Case Report
Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats.
Jeong Seung-Hyun, Jang Ji-Hun, Lee Yong-Bok · Pharmaceuticals (Basel) · 2020
PMID: 32887301OtherFull text (PMC)
A Novel Polymer-Lipid Hybrid Nanoparticle for the Improvement of Topotecan Hydrochloride Physicochemical Properties.
Silva Emanuelle Jesus, Souza Leonardo Gomes, Silva Luis Antonio Dantas et al. · Curr Drug Deliv · 2018
PMID: 29243576Other
Fluorescent reversible regulation based on the interactions of topotecan hydrochloride, neutral red and quantum dots.
Wang Linlin, Shen Yizhong, Liu Shaopu et al. · Spectrochim Acta A Mol Biomol Spectrosc · 2015
PMID: 25459722Other
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor.
Tan Hanyi, Wang Guolin, Li Jiajun et al. · Bioorg Med Chem · 2015
PMID: 25481395Other
A study of variable hydration states in topotecan hydrochloride.
Vogt Frederick G, Dell'Orco Philip C, Diederich Ann M et al. · J Pharm Biomed Anal · 2006
PMID: 16242889Other
Topotecan hydrochloride effects on retinal vessels in newborn rats.
Pescosolido N, Pascarella A, Scarsella G et al. · Histol Histopathol · 2012
PMID: 22374727Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Topotecan hydrochloride (substance)
SNOMED CT
108781007
UMLS CUI
C0886549

Clinical Data

This intervention maps to 5 entities in the Healos knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.