Substance / Medication

Trabectedin

Overview

Active Ingredient
trabectedin
RxNorm CUI
1716278

Indications

® Clinical Studies (14) [see] YONDELISis indicated for the treatment of adult patients with unresectable or metastatic liposarcoma or leiomyosarcoma who received a prior anthracycline-containing regimen.

Labeler: Janssen Products, LPUpdated: 2026-01-06T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

YONDELIS is contraindicated in patients with known severe hypersensitivity, including anaphylaxis, to trabectedin.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Meta-analysis of pazopanib and trabectedin effectiveness in previously treated metastatic synovial sarcoma (second-line setting and beyond).
Carroll Charlotte, Patel Nashita, Gunsoy Necdet B et al. · Future Oncol · 2022
PMID: 36399116Meta-Analysis
Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of trabectedin (ET-743, Yondelis) induced neutropenia.
Hing J, Perez-Ruixo J J, Stuyckens K et al. · Clin Pharmacol Ther · 2008
PMID: 17597713Meta-Analysis
Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients.
Perez-Ruixo Juan Jose, Zannikos Peter, Hirankarn Sarapee et al. · Clin Pharmacokinet · 2007
PMID: 17854236Meta-Analysis
Doxorubicin-Trabectedin with Trabectedin Maintenance in Leiomyosarcoma.
Pautier Patricia, Italiano Antoine, Piperno-Neumann Sophie et al. · N Engl J Med · 2024
PMID: 39231341RCT
Efficacy and safety of trabectedin as an early treatment for advanced or metastatic liposarcoma and leiomyosarcoma.
Blay Jean Yves, Casali Paolo, Nieto Antonio et al. · Future Oncol · 2014
PMID: 23987833RCT
Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies.
Thertulien R, Manikhas G M, Dirix L Y et al. · Cancer Chemother Pharmacol · 2012
PMID: 21739119RCTFull text (PMC)
Relative Dose Intensity of Trabectedin and Outcome of Advanced L-Sarcomas.
Poitureau Stephen, Le Deley Marie-Cécile, Brahmi Mehdi et al. · Cancer Med · 2025
PMID: 40827456ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trabectedin (substance)
SNOMED CT
433127001
UMLS CUI
C1311070
RxNorm CUI
1716278
Labeler
Janssen Products, LP

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.