Substance / Medication

Valproic acid

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Valproic acid-induced oxidative stress: Systematic review, meta-analysis and network pharmacology highlights disruption in antioxidant pathways in rodents.
Asghar Muhammad Arif, Tang Shixin, Wan Bing et al. · Toxicol Appl Pharmacol · 2025
PMID: 39557347Meta-Analysis
Effect of valproic acid and levetiracetam administration on the survival of glioma patients: a meta-analysis study.
Shirani Arya, Obeidinia Mobin, Ziafati Makan et al. · Anticancer Drugs · 2025
PMID: 40699178Meta-Analysis
Valproic acid-induced hyperammonemia with encephalopathy in adults: A meta-analysis.
Huang Tsai-Kuei, Su Yi-Chia, Shih Ching-Sen · Int J Clin Pharmacol Ther · 2025
PMID: 39873559Meta-Analysis
Safety of Valproic Acid Use in Pregnant Women: A Systematic Review and Meta-Analysis.
Yang Xinying, Sun Yiqi, Hua Zixin et al. · J Obstet Gynaecol Res · 2025
PMID: 41161707Meta-Analysis
Effects of Valproic Acid Therapy on Rats with Spinal Cord Injury: A Systematic Review and Meta-Analysis.
Yang Qinglin, Zhang Huaibin, Jin Zhuanmei et al. · World Neurosurg · 2024
PMID: 37923014Meta-Analysis
Anatomical, behavioral, and cognitive teratogenicity associated with valproic acid: a systematic review.
Valentino Kyle, Teopiz Kayla M, Kwan Angela T H et al. · CNS Spectr · 2024
PMID: 39727238Meta-Analysis
Kidney tubular injury induced by valproic acid: systematic literature review.
Anguissola Giulia, Leu Dennis, Simonetti Giacomo D et al. · Pediatr Nephrol · 2023
PMID: 36645492Meta-AnalysisFull text (PMC)
Clinical Pharmacokinetic Monitoring of Free Valproic Acid Levels: A Systematic Review.
Lin Kevin, Cao Vivien F S, Au Charles et al. · Clin Pharmacokinet · 2022
PMID: 36040614Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Valproic acid (substance)
SNOMED CT
387080000
UMLS CUI
C0042291

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

5
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.