Substance / Medication

Vitamin B12a

Overview

Active Ingredient
hydroxocobalamin
RxNorm CUI
5514

Indications

CYANOKIT is indicated for the treatment of known or suspected cyanide poisoning.

Labeler: BTG INTERNATIONAL INC.Updated: 2023-04-27T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
[Effectiveness of cortexin in the complex treatment of patients with chronic alcohol encephalopathy and polyneuropathy].
Solov'ev A G, Elistratova T V · Zh Nevrol Psikhiatr Im S S Korsakova · 2010
PMID: 20517210RCT
[The tebantin use in the complex therapy of pain syndrome during the mixed forms of alcoholic polyneuropathy].
Barsukov I N, Kashin A V, Kostiuk G P · Voen Med Zh · 2006
PMID: 17236668RCT
Aquacobalamin (vitamin B12a) does not bind NO in aqueous solution. Nitrite impurities account for observed reaction.
Wolak M, Stochel G, Hamza M et al. · Inorg Chem · 2000
PMID: 12526506Observational
[Thiamine (vitamin B1) treatment in patients with alcohol dependence].
Dervaux Alain, Laqueille Xavier · Presse Med · 2017
PMID: 27818067Review
[Neurological diseases and nutrition -- what can we do?].
Tamási Péter · Orv Hetil · 2014
PMID: 25497154Review
Use of Hydroxocobalamin (Vitamin B12a) in Patients With Vasopressor Refractory Hypotension After Cardiopulmonary Bypass: A Case Series.
Armour Sarah, Armour Trygve K, Joppa William R et al. · Anesth Analg · 2019
PMID: 29979199Other
The synthesis of a corrole analogue of aquacobalamin (vitamin B12a) and its ligand substitution reactions.
Zipp Caitlin F, Michael Joseph P, Fernandes Manuel A et al. · Inorg Chem · 2014
PMID: 24721109Other
[Intravenous administration of vitamin B12a in cases of cyanide poisoning].
Bugarín González R, Portela Romero M, Martínez Varela F et al. · Aten Primaria · 2005
PMID: 15871806OtherFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Hydroxocobalamin (substance)
SNOMED CT
1217428002
UMLS CUI
C0020316
RxNorm CUI
5514
Labeler
BTG INTERNATIONAL INC.

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

5
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.