Substance / Medication

Zolmitriptan

Overview

Active Ingredient
zolmitriptan
RxNorm CUI
135775

Indications

Zolmitriptan tablets are indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use • Only use zolmitriptan tablets if a clear diagnosis of migraine has been established. If a patient has no response to zolmitriptan tablets treatment for the first migraine attack, reconsider the diagnosis of migraine before zolmitriptan tablets are administered to treat any subsequent attacks. • Zolmitriptan tablets are not indicated for the prevention of migraine attacks. •

Labeler: Glenmark Pharmaceuticals Inc.,USAUpdated: 2026-01-29T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Zolmitriptan tablets are contraindicated in patients with: • c 5.1 Warnings and Precautions () Ischemic coronary artery disease (angina pectoris, history of myocardial infarction, or documented silent ischemia), other significant underlying cardiovascular disease, ororonary artery vasospasm includin

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

3 trials linked to this intervention

3
Total Trials
0
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Zolmitriptan for acute migraine attacks in adults.
Bird Sarah, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2014
PMID: 24848613Meta-AnalysisFull text (PMC)
Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies.
Hedlund Cecilia, Rapoport Alan M, Dodick David W et al. · Headache · 2009
PMID: 19788472Meta-Analysis
Meta-analysis of the efficacy and safety of zolmitriptan in the acute treatment of migraine.
Chen Li-Chia, Ashcroft Darren M · Headache · 2008
PMID: 18179569Meta-Analysis
Limited effects of zolmitriptan maintenance on the pharmacodynamic profile of intravenous cocaine in humans.
Stoops William W, Lile Joshua A, Alcorn Joseph L et al. · Behav Pharmacol · 2026
PMID: 41401392RCTFull text (PMC)
Buspirone and Zolmitriptan Combination for Dyskinesia: A Randomized, Controlled, Crossover Study.
LeWitt Peter A, Stebbins Glenn T, Christensen Kenneth Vielsted et al. · Mov Disord · 2024
PMID: 38314643RCT
Zolmitriptan inhibits neurogenic inflammation and pain during electrical stimulation in human skin.
Döring K, Best C, Birklein F et al. · Eur J Pain · 2015
PMID: 25395191RCT
Zolmitriptan compared to propranolol in the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study.
Avital Ayelet, Gross-Isseroff Ruth, Stryjer Rafael et al. · Eur Neuropsychopharmacol · 2009
PMID: 19342206RCT
Patient preference for triptan formulations: a prospective study with zolmitriptan.
Dowson Andrew, Bundy Michael, Salt Rebecca et al. · Headache · 2007
PMID: 17883519RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Zolmitriptan (substance)
SNOMED CT
363582006
UMLS CUI
C0528166
RxNorm CUI
135775
Labeler
Glenmark Pharmaceuticals Inc.,USA

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.