IGF-1, LC/MS

Insulin-like growth factor (IGF-1) is a hormone produced primarily by the liver that promotes growth and development throughout life. Blood IGF-1 levels reflect growth hormone status and overall metabolic health. Low levels may indicate growth hormone deficiency, malnutrition, or liver disease, while elevated levels can suggest growth hormone excess or certain tumors. This test is used to evaluate growth disorders, aging-related health concerns, and metabolic function. Results must be interpreted with age and sex considerations.

Insulin-like growth factor-I (IGF-1) is a hormone produced by the liver in response to growth hormone, mediating growth hormone's effects on growth and metabolism. An IGF-1 test screens for growth hormone disorders. Low IGF-1 suggests growth hormone deficiency, causing short stature in children or reduced muscle mass, strength, and metabolic dysfunction in adults. High IGF-1 may indicate excess growth hormone (acromegaly or gigantism), causing enlarged extremities and organs. Normal ranges vary widely by age, sex, and puberty stage, complicating interpretation. IGF-1 is useful for screening, though diagnosis requires additional testing and dynamic assessment.