Ttg IgG Antibody Test

This test measures antibodies (IgA and IgG) against tissue transglutaminase (tTG), a protein involved in celiac disease. When people with celiac disease consume gluten, their immune system attacks this protein, producing these antibodies. Elevated levels are highly suggestive of celiac disease or dermatitis herpetiformis. This is the primary screening test for celiac disease and helps confirm diagnosis in those with symptoms like digestive issues, fatigue, or nutrient deficiencies.

Tissue transglutaminase (tTG) antibodies are markers of celiac disease, an autoimmune disorder triggered by gluten consumption. When people with celiac disease eat gluten (found in wheat, barley, and rye), their immune system produces antibodies against tTG, damaging the small intestine. This antibody panel test typically includes IgA anti-tTG and/or IgG anti-tTG. A positive result suggests celiac disease and should be confirmed with intestinal biopsy. This test is essential for diagnosing celiac disease before it causes complications like nutritional deficiencies, osteoporosis, or increased cancer risk.

This test detects antibodies (IgA and IgG) against gliadin and tissue transglutaminase, key markers for celiac disease screening. When people with celiac disease consume gluten, their immune system attacks intestinal tissue and produces these antibodies. A positive result strongly suggests celiac disease and warrants further testing with small intestinal biopsy for confirmation. Early detection is important because untreated celiac disease can cause intestinal damage, nutrient malabsorption, and long-term complications including osteoporosis and increased infection risk.