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ROLAND PIXLEY, MD

MD

Obstetrics & Gynecology Physician

NPI: 1023034311Individual

Specialties, Licenses & Credentials

Obstetrics & Gynecology PhysicianPrimary

Obstetrics & Gynecology

Code: 207V00000X

31355(NC)

Research & Publications (20)

Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.
PMID 19483730·Oncogene·2009
8-other
A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A.
PMID 18394675·Bioorg Chem·2008
8-other
The inhibition of tube formation in a collagen-fibrinogen, three-dimensional gel by cleaved kininogen (HKa) and HK domain 5 (D5) is dependent on Src family kinases.
PMID 18062965·Exp Cell Res·2008
8-other
Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology.
PMID 17597995·Thromb Haemost·2007
6-review
Domain 5 of kininogen inhibits proliferation of human colon cancer cell line (HCT-116) by interfering with G1/S in the cell cycle.
PMID 17155949·J Thromb Haemost·2007
8-other
New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A: a role for the unique 44-amino acid insert.
PMID 16873361·J Biol Chem·2006
8-other
Multiple myeloma in a murine syngeneic model:modulation of growth and angiogenesis by a monoclonal antibody to kininogen.
PMID 16187087·Cancer Immunol Immunother·2006
7-preclinical
Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis.
PMID 16059911·Arthritis Rheum·2005
7-preclinical
A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat.
PMID 15987478·Arthritis Res Ther·2005
4-observational
A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis.
PMID 15331420·Am J Pathol·2004
4-observational
Inhibition of tumor angiogenesis in vivo by a monoclonal antibody targeted to domain 5 of high molecular weight kininogen.
PMID 15161672·Blood·2004
7-preclinical
Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis.
PMID 15001555·FASEB J·2004
7-preclinical
High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib.
PMID 12952972·J Biol Chem·2003
7-preclinical
Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc.
PMID 12911595·J Thromb Haemost·2003
8-other
Inhibition of angiogenesis by antibody blocking the action of proangiogenic high-molecular-weight kininogen.
PMID 12871554·J Thromb Haemost·2003
7-preclinical
The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation.
PMID 12842992·Blood·2003
7-preclinical
Chronic intestinal inflammation and angiogenesis in genetically susceptible rats is modulated by kininogen deficiency.
PMID 12489803·Int Immunopharmacol·2002
7-preclinical
A novel antithrombotic role for high molecular weight kininogen as inhibitor of plasminogen activator inhibitor-1 function.
PMID 12082110·J Biol Chem·2002
8-other
Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.
PMID 12065305·Am J Physiol Gastrointest Liver Physiol·2002
4-observational
Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen.
PMID 11970955·J Biol Chem·2002
8-other

Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.

Contact & Hours

Via practice · 5 locations total

Address
1025 MOREHEAD MEDICAL DR, STE 400
CHARLOTTE, NC 28204

Locations (5)

Practice Location

1025 MOREHEAD MEDICAL DR, CHARLOTTE, NC
(704) 446-1700

Practice Location

9908 COULOAK DR, CHARLOTTE, NC
(704) 801-2075

Practice Location

4525 CAMERON VALLEY PKWY, CHARLOTTE, NC
(704) 446-1700

Practice Location

7810 PROVIDENCE RD, CHARLOTTE, NC
(704) 446-1700

Practice Location

16455 STATESVILLE RD, HUNTERSVILLE, NC
(704) 896-3370

Quick Facts

NPI
1023034311
Entity Type
Individual
Gender
Male
Medicare
Not confirmed
Specialties
1
Locations
5
Publications
20

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