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MICHAEL AXELSON M.D.
M.D.
Medical Oncology Physician
NPI: 1073615654Individual
Specialties, Licenses & Credentials
Internal Medicine Physician
Internal Medicine
Code: 207R00000X
4301087311(MI)
Medical Oncology PhysicianPrimary
Internal Medicine — Medical Oncology
Code: 207RX0202X
2012-00964(NC)
Research & Publications (20)
Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.
PMID 19302825·Exp Cell Res·2009
7-preclinical
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
PMID 19032681·Acta Ophthalmol·2008
7-preclinical
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
PMID 19032680·Acta Ophthalmol·2008
4-observational
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
PMID 19032679·Acta Ophthalmol·2008
7-preclinical
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
PMID 18515591·Invest Ophthalmol Vis Sci·2008
7-preclinical
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
PMID 18515579·Invest Ophthalmol Vis Sci·2008
4-observational
CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.
PMID 18331353·FEBS J·2008
7-preclinical
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
PMID 18267106·Biochem Biophys Res Commun·2008
4-observational
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
PMID 17828296·Oncogene·2008
7-preclinical
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
PMID 18070930·Mol Pharmacol·2008
8-other
Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.
PMID 17023532·Endocrinology·2007
7-preclinical
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.
PMID 17606126·J Vasc Surg·2007
7-preclinical
Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival.
PMID 17546599·Int J Cancer·2007
4-observational
Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat.
PMID 17108234·J Pharmacol Exp Ther·2007
7-preclinical
Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin "flushes".
PMID 18000622·Thromb Haemost·2007
5-case
The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
PMID 16407828·Oncogene·2006
8-other
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
PMID 16046527·Blood·2006
4-observational
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
PMID 16166596·Blood·2006
8-other
GH effect on enzyme activity of 11betaHSD in abdominal obesity is dependent on treatment duration.
PMID 16381993·Eur J Endocrinol·2006
2-rct
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 2711 RANDOLPH RD, SUITE 100
CHARLOTTE, NC 28207 - Phone
- (704) 342-1900
Quick Facts
- NPI
- 1073615654
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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