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WILLIAM HUMPHREYS, M.D.

M.D.

Orthopaedic Surgery Physician

NPI: 1235131814Individual

Specialties, Licenses & Credentials

Orthopaedic Surgery PhysicianPrimary

Orthopaedic Surgery

Code: 207X00000X

36614(MO)

Research & Publications (20)

Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections.
PMID 19251818·Drug Metab Dispos·2009
7-preclinical
Apixaban metabolism and pharmacokinetics after oral administration to humans.
PMID 18832478·Drug Metab Dispos·2009
8-other
Metabolism and excretion of an oral taxane analog, [14C]3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in rats and dogs.
PMID 19196843·Drug Metab Dispos·2009
4-observational
Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.
PMID 19420130·Drug Metab Dispos·2009
3-trial
Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
PMID 19576871·Chem Biol Interact·2009
7-preclinical
In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.
PMID 19253935·Chem Res Toxicol·2009
8-other
Fine-scale comparative phylogeography of a sympatric sister species triplet of subterranean diving beetles from a single calcrete aquifer in Western Australia.
PMID 19674311·Mol Ecol·2009
7-preclinical
CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).
PMID 19158314·Drug Metab Dispos·2009
8-other
The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.
PMID 19608696·Drug Metab Dispos·2009
7-preclinical
Sulfation of o-demethyl apixaban: enzyme identification and species comparison.
PMID 19131519·Drug Metab Dispos·2009
4-observational
Algorithm for thorough background subtraction of high-resolution LC/MS data: application to obtain clean product ion spectra from nonselective collision-induced dissociation experiments.
PMID 19254033·Anal Chem·2009
8-other
Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats.
PMID 18787054·Drug Metab Dispos·2008
7-preclinical
Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds.
PMID 18989850·Biopharm Drug Dispos·2008
7-preclinical
Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2.
PMID 18707880·Bioorg Med Chem Lett·2008
4-observational
Metabolism and disposition of dasatinib after oral administration to humans.
PMID 18420784·Drug Metab Dispos·2008
8-other
Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys.
PMID 18420785·Drug Metab Dispos·2008
7-preclinical
The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development.
PMID 18451235·Clin Cancer Res·2008
3-trial
(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.
PMID 18554903·Bioorg Med Chem Lett·2008
7-preclinical
Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics.
PMID 18556438·Drug Metab Dispos·2008
8-other
Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer.
PMID 18416441·J Mass Spectrom·2008
7-preclinical

Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.

Contact & Hours

Via practice · 5 locations total

Address
2016 S MAIN ST
MARYVILLE, MO 64468

Locations (5)

Practice Location

2016 S MAIN ST, MARYVILLE, MO
(660) 562-2525

Practice Location

114 E SOUTH HILLS DR, MARYVILLE, MO
(660) 562-2525

Practice Location

2016 S MAIN ST, MARYVILLE, MO
(660) 562-2600

Practice Location

3107 FREDERICK AVE, SAINT JOSEPH, MO
(816) 233-9888

Practice Location

301 E Price Ave, Savannah, MO
(816) 432-0006

Quick Facts

NPI
1235131814
Entity Type
Individual
Gender
Male
Medicare
Not confirmed
Specialties
1
Locations
5
Publications
20

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