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BRIANA AKILI MALCOLM DO
DO
Pediatrics Physician
NPI: 1396485694Individual
Specialties, Licenses & Credentials
Student in an Organized Health Care Education/Training Program
Student in an Organized Health Care Education/Training Program
Code: 390200000X
Pediatrics PhysicianPrimary
Pediatrics
Code: 208000000X
0102209209(VA)
Research & Publications (20)
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
PMID 18421139·J Synchrotron Radiat·2008
8-other
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
PMID 17444623·J Med Chem·2007
8-other
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
PMID 17004721·J Med Chem·2006
7-preclinical
Multiple substance dependence and course of alcoholism among Alaska native men and women.
PMID 16603457·Subst Use Misuse·2006
8-other
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
PMID 16352601·J Biol Chem·2006
8-other
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034.
PMID 16448708·Antiviral Res·2006
8-other
Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors.
PMID 16445277·Biochemistry·2006
8-other
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells.
PMID 16495264·Antimicrob Agents Chemother·2006
8-other
Trans-complementation of HCV replication by non-structural protein 5A.
PMID 16146661·Virus Res·2006
8-other
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.
PMID 16087332·Bioorg Med Chem Lett·2005
8-other
Development of a fluorescence polarization bead-based coupled assay to target different activity/conformation states of a protein kinase.
PMID 15191648·J Biomol Screen·2004
8-other
Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.
PMID 14694101·J Virol·2004
8-other
A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
PMID 14751259·Anal Biochem·2004
8-other
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.
PMID 12781720·Virology·2003
8-other
Dosage of treatment to sexual offenders: are we overprescribing?
PMID 12710363·Int J Offender Ther Comp Criminol·2003
8-other
Quantitative estimation of viral fitness using Pyrosequencing.
PMID 12545532·Biotechniques·2003
4-observational
Two-stage polymerase chain reaction protocol allowing introduction of multiple mutations, deletions, and insertions, using QuikChange site-directed mutagenesis.
PMID 11768973·Methods Mol Biol·2002
8-other
Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors.
PMID 12488004·Biophys Chem·2002
8-other
Hepatitis C virus whole genome position weight matrix and robust primer design.
PMID 12323075·BMC Microbiol·2002
8-other
Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity.
PMID 11276078·Proteins·2001
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
Via practice · 2 locations total
- Address
- 22 S GREENE ST
BALTIMORE, MD 21201 - Phone
- (410) 328-6960
Quick Facts
- NPI
- 1396485694
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 2
- Publications
- 20
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