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DR. JAMES A. CHAMPOUX M.D.
M.D.
Orthopaedic Surgery Physician
NPI: 1396773768Individual
Specialties, Licenses & Credentials
Orthopaedic Surgery PhysicianPrimary
Orthopaedic Surgery
Code: 207X00000X
MD00021526(WA)
Research & Publications (20)
Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription.
PMID 19228195·FEBS J·2009
6-review
Type IA DNA topoisomerases: strictly one step at a time.
PMID 12221296·Proc Natl Acad Sci U S A·2002
8-other
A first view of the structure of a type IA topoisomerase with bound DNA.
PMID 12007989·Trends Pharmacol Sci·2002
8-other
DNA topoisomerase I-mediated nicking of circular duplex DNA.
PMID 11089222·Methods Mol Biol·2001
8-other
Structure-based analysis of the effects of camptothecin on the activities of human topoisomerase I.
PMID 11193925·Ann N Y Acad Sci·2000
6-review
Arylstibonic acids: novel inhibitors and activators of human topoisomerase IB.
PMID 18508107·Bioorg Chem·2008
8-other
RNase H activity: structure, specificity, and function in reverse transcription.
PMID 18261820·Virus Res·2008
6-review
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
PMID 17948061·EMBO J·2007
4-observational
Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.
PMID 17532359·Virology·2007
7-preclinical
The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA.
PMID 16487540·J Mol Biol·2006
7-preclinical
Pausing during reverse transcription increases the rate of retroviral recombination.
PMID 16474155·J Virol·2006
8-other
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.
PMID 16306040·J Biol Chem·2006
8-other
Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.
PMID 16141202·J Biol Chem·2005
8-other
SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.
PMID 15920477·EMBO J·2005
8-other
Human DNA topoisomerase I: relaxation, roles, and damage control.
PMID 15830206·Chromosoma·2005
6-review
Effects of unpaired nucleotides within HIV-1 genomic secondary structures on pausing and strand transfer.
PMID 15542863·J Biol Chem·2005
8-other
Single unpaired nucleotides facilitate HIV-1 reverse transcriptase displacement synthesis through duplex RNA.
PMID 15169769·J Biol Chem·2004
8-other
The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
PMID 14594810·J Biol Chem·2004
8-other
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
PMID 14761185·J Med Chem·2004
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 12911 120TH AVE NE, H-210
KIRKLAND, WA 98034 - Phone
- (425) 823-4000
Quick Facts
- NPI
- 1396773768
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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