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MATTHEW CROUTHAMEL, MD
MD
Surgery Physician
NPI: 1437264322IndividualAccepts Medicare
Specialties, Licenses & Credentials
Surgery PhysicianPrimary
Surgery
Code: 208600000X
M15179(ID)MD00047066(WA)MD471575(PA)
CMS Specialties
PrimaryGENERAL SURGERY
Education
UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE
Class of 2004
Research & Publications (20)
A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells.
PMID 16917872·J Pharm Sci·2006
8-other
MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.
PMID 19123050·Cancer Chemother Pharmacol·2009
7-preclinical
Mechanism and management of AKT inhibitor-induced hyperglycemia.
PMID 19118049·Clin Cancer Res·2009
7-preclinical
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
PMID 18854490·J Pharmacol Exp Ther·2009
7-preclinical
N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).
PMID 18647648·Cell Signal·2008
8-other
In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
PMID 18156464·J Pharmacol Exp Ther·2008
4-observational
Evaluating scoring functions for docking and designing beta-secretase inhibitors.
PMID 17107793·Bioorg Med Chem Lett·2007
8-other
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.
PMID 17620431·Mol Cancer Ther·2007
7-preclinical
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
PMID 17583334·J Med Chem·2007
7-preclinical
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
PMID 17482814·Bioorg Med Chem Lett·2007
8-other
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
PMID 17149856·J Med Chem·2006
8-other
Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.
PMID 17034118·J Med Chem·2006
7-preclinical
A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
PMID 16300640·J Neurochem·2006
7-preclinical
Conformationally biased P3 amide replacements of beta-secretase inhibitors.
PMID 16263281·Bioorg Med Chem Lett·2006
8-other
Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
PMID 15958191·Anal Biochem·2005
4-observational
Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
PMID 15851852·J Alzheimers Dis·2005
7-preclinical
Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.
PMID 15737955·J Biol Chem·2005
8-other
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
PMID 15588077·J Med Chem·2004
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 910 W 5TH AVE STE 800
SPOKANE, WA 99204 - Phone
- (509) 755-5120
Quick Facts
- NPI
- 1437264322
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Accepted
- Specialties
- 3
- Locations
- 1
- Years in Practice
- 22
- Publications
- 20
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