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JENNIFER VACCA, MD
MD
Internal Medicine Physician
NPI: 1528251873Individual
Specialties, Licenses & Credentials
Internal Medicine PhysicianPrimary
Internal Medicine
Code: 207R00000X
48229(CO)4301511266(MI)
Research & Publications (20)
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
PMID 19409780·Bioorg Med Chem Lett·2009
8-other
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
PMID 19577468·Bioorg Med Chem Lett·2009
7-preclinical
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
PMID 19631528·Bioorg Med Chem Lett·2009
8-other
The discovery of highly potent CGRP receptor antagonists.
PMID 19010673·Bioorg Med Chem Lett·2009
7-preclinical
Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
PMID 19085994·ChemMedChem·2009
7-preclinical
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
PMID 18854490·J Pharmacol Exp Ther·2009
7-preclinical
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
PMID 18590336·Org Lett·2008
8-other
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
PMID 18774711·Bioorg Med Chem Lett·2008
7-preclinical
Potent benzimidazolone-based CGRP receptor antagonists.
PMID 18947992·Bioorg Med Chem Lett·2008
7-preclinical
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
PMID 18811140·J Med Chem·2008
8-other
Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.
PMID 18039571·Bioorg Med Chem Lett·2008
7-preclinical
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
PMID 18657970·Bioorg Med Chem Lett·2008
7-preclinical
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
PMID 18826204·J Med Chem·2008
7-preclinical
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
PMID 18396399·Bioorg Med Chem Lett·2008
8-other
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
PMID 18078751·Bioorg Med Chem Lett·2008
8-other
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
PMID 18083561·Bioorg Med Chem Lett·2008
8-other
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.
PMID 18338894·J Am Chem Soc·2008
7-preclinical
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
PMID 18039958·J Pharmacol Exp Ther·2008
4-observational
Bismacrocyclic inhibitors of hepatitis C NS3/4a protease.
PMID 18925594·Angew Chem Int Ed Engl·2008
8-other
PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study.
PMID 19040279·J Med Virol·2008
4-observational
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 401 HALL ST SW STE 263
GRAND RAPIDS, MI 49503 - Phone
- (616) 719-0919
Quick Facts
- NPI
- 1528251873
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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