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WILLIAM PENDERGRAFT, M.D., PH.D.
M.D., PH.D.
Internal Medicine Physician
NPI: 1578899282Individual
Specialties, Licenses & Credentials
Internal Medicine PhysicianPrimary
Internal Medicine
Code: 207R00000X
2013-02226(NC)
Nephrology Physician
Internal Medicine — Nephrology
Code: 207RN0300X
195405(NC)
Research & Publications (11)
Autoantigen complementarity: a new theory implicating complementary proteins as initiators of autoimmune disease.
PMID 15592920·J Mol Med (Berl)·2005
6-review
Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis.
PMID 14675038·Kidney Int·2004
8-other
Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.
PMID 14661018·Nat Med·2004
7-preclinical
ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells.
PMID 10792617·Kidney Int·2000
8-other
A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein.
PMID 17966040·Autoimmunity·2007
8-other
Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system.
PMID 17591979·Am J Pathol·2007
8-other
New insights that link microbes with the generation of antineutrophil cytoplasmic autoantibodies: the theory of autoantigen complementarity.
PMID 15821413·Curr Opin Nephrol Hypertens·2005
6-review
Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis.
PMID 15284296·J Am Soc Nephrol·2004
8-other
Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways.
PMID 12444202·J Am Soc Nephrol·2002
8-other
Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants.
PMID 11159195·Am J Pathol·2001
8-other
Expression of p300-truncated fragments results in the modulation of apoptosis in rat mesangial cells.
PMID 10792606·Kidney Int·2000
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
Via practice · 2 locations total
- Address
- Unc Kidney Ctr, 7024 Burnett Womack Building, Campus Box # 7155
Chapel Hill, NC 27599 - Phone
- (919) 966-2561
Quick Facts
- NPI
- 1578899282
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 2
- Publications
- 11
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