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RALPH A DEFRONZO MD
MD
Endocrinology, Diabetes & Metabolism Physician
NPI: 1851408843Individual
Specialties, Licenses & Credentials
Endocrinology, Diabetes & Metabolism PhysicianPrimary
Internal Medicine — Endocrinology, Diabetes & Metabolism
Code: 207RE0101X
H7531(TX)
Clinical Trials (5)
5
Linked Trials
1
Recruiting
4
With Results
Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DM
NCT01107717COMPLETEDPHASE4PRINCIPAL_INVESTIGATOR
Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration
NCT02911792COMPLETEDPHASE4PRINCIPAL_INVESTIGATOR
PROTOCOL 3: Role of the Renal Nerves in the Increase in EGP in Response to Glucosuria
NCT03168295COMPLETEDPHASE4PRINCIPAL_INVESTIGATOR
Effect of Cycloset on Glycemic Control When Added to Glucagon-like Peptide 1 (GLP-1) Analogue Therapy
NCT02299050COMPLETEDPHASE4PRINCIPAL_INVESTIGATOR
Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
NCT05838287RECRUITINGPHASE4PRINCIPAL_INVESTIGATOR
Research & Publications (20)
Glycemic and non-glycemic benefits of initial triple therapy versus sequential add-on therapy in patients with new-onset diabetes: results from the EDICT study.
PMID 40288809·BMJ Open Diabetes Res Care·2025
3-trial
Durability of Triple Combination Therapy Versus Stepwise Addition Therapy in Patients With New-Onset T2DM: 3-Year Follow-up of EDICT.
PMID 33273042·Diabetes Care·2021
2-rct
Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy.
PMID 32827269·Diabetologia·2020
2-rct
Increase in Endogenous Glucose Production With SGLT2 Inhibition Is Unchanged by Renal Denervation and Correlates Strongly With the Increase in Urinary Glucose Excretion.
PMID 32144165·Diabetes Care·2020
2-rct
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus.
PMID 24334175·Circulation·2014
3-trial
Sodium glucose transport 2 (SGLT2) inhibition decreases glomerular hyperfiltration: is there a role for SGLT2 inhibitors in diabetic kidney disease?
PMID 24334174·Circulation·2014
8-other
Glomerular hyperfiltration and renal disease progression in type 2 diabetes.
PMID 22773704·Diabetes Care·2012
2-rct
Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat.
PMID 21940401·Am J Physiol Regul Integr Comp Physiol·2012
7-preclinical
Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes.
PMID 21606218·Endocr Rev·2011
6-review
Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis.
PMID 19198800·Diabetologia·2009
1-meta
Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats.
PMID 18769499·Exp Diabetes Res·2008
7-preclinical
Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists.
PMID 10792600·Kidney Int·2000
6-review
The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone.
PMID 19478198·Diabetes Care·2009
2-rct
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
PMID 19336687·Diabetes·2009
8-other
Actos Now for the prevention of diabetes (ACT NOW) study.
PMID 19640291·BMC Endocr Disord·2009
8-other
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.
PMID 18809631·Diabetes Care·2008
2-rct
Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study.
PMID 18786299·Curr Med Res Opin·2008
3-trial
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.
PMID 15855572·Diabetes Care·2005
3-trial
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 701 S ZARZAMORA ST
SAN ANTONIO, TX 78207 - Phone
- (210) 358-7500
Quick Facts
- NPI
- 1851408843
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Clinical Trials
- 5
- Publications
- 20
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