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ALEXANDER CAPELL, MD
MD
Emergency Medicine Physician
NPI: 1942733159IndividualAccepts Medicare
Education
OTHER
Class of 2017
Research & Publications (20)
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
PMID 19522733·J Neurochem·2009
4-observational
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
PMID 17984093·J Biol Chem·2008
7-preclinical
A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
PMID 16777847·J Biol Chem·2006
7-preclinical
Gamma-secretase complex assembly within the early secretory pathway.
PMID 15591316·J Biol Chem·2005
8-other
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
PMID 15549135·EMBO J·2004
7-preclinical
CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk.
PMID 15350543·Exp Cell Res·2004
7-preclinical
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.
PMID 14602727·J Biol Chem·2003
8-other
Gamma-secretase activity is associated with a conformational change of nicastrin.
PMID 12644462·J Biol Chem·2003
8-other
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
PMID 12223485·J Biol Chem·2002
7-preclinical
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
PMID 12147673·J Cell Biol·2002
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
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Contact & Hours
- Address
- 2600 NAVARRE AVE
OREGON, OH 43616 - Phone
- (419) 696-7411
Quick Facts
- NPI
- 1942733159
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Accepted
- Specialties
- 1
- Locations
- 1
- Years in Practice
- 9
- Publications
- 20
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