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Eaton-Lambert syndrome

disorder
SNOMED 56989000CUI C0022972

Overview

Eaton-Lambert syndrome is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Research Evidence

Peer-reviewed studies linked via MeSH term "Lambert-Eaton Myasthenic Syndrome" from the MEDLINE/PubMed database.

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The management of Lambert Eaton syndrome in the setting of hypertensive disorders of pregnancy: A literature review.
[object Object], [object Object], [object Object] et al. · Pregnancy Hypertens · 2025
PMID: 40946449Meta-Analysis
3,4-diaminopyridine treatment for Lambert-Eaton myasthenic syndrome in adults: a meta-analysis of randomized controlled trials.
[object Object], [object Object], [object Object] et al. · BMC Neurol · 2021
PMID: 34563155Meta-AnalysisFull text (PMC)
Treatment for Lambert-Eaton myasthenic syndrome.
[object Object], [object Object], [object Object] · Cochrane Database Syst Rev · 2011
PMID: 21328260Meta-AnalysisFull text (PMC)
Treatment for Lambert-Eaton myasthenic syndrome.
[object Object], [object Object] · Cochrane Database Syst Rev · 2005
PMID: 15846654Meta-Analysis
Treatment for Lambert-Eaton myasthenic syndrome.
[object Object], [object Object] · Cochrane Database Syst Rev · 2003
PMID: 12804456Meta-Analysis
3,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia.
[object Object], [object Object], [object Object] et al. · Muscle Nerve · 2018
PMID: 29280483RCTFull text (PMC)
The recognition, physiology, and treatment of Lambert-Eaton myasthenic syndrome.
[object Object] · Dis Mon · 2025
PMID: 40544116Review
Lambert Eaton Myasthenic Syndrome.
[object Object], [object Object] · Int Rev Neurobiol · 2025
PMID: 40675738Review
[Blood-brain barrier breakdown and autoimmune cerebellar ataxia].
[object Object] · Rinsho Shinkeigaku · 2024
PMID: 38403685Review

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Autonomic dysregulation
Very frequent (80-99%)HP:0012332
Calcium channel antibody positivity
Very frequent (80-99%)HP:0030209
Diminished deep tendon reflexes
Very frequent (80-99%)HP:0001315
EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
Very frequent (80-99%)HP:0003403
EMG: repetitive nerve stimulation abnormality
Very frequent (80-99%)HP:0030000
Muscle weakness, progressive, proximal
Very frequent (80-99%)HP:0009073
Xerostomia
Very frequent (80-99%)HP:0000217
Abnormality of the orbital region
Frequent (30-79%)HP:0000315
Anti-P/Q-type VGCC antibody positivity
Frequent (30-79%)HP:5000027
Bulbar signs
Frequent (30-79%)HP:0002483
Difficulty getting an erection
Frequent (30-79%)HP:0000802
Dyschezia
Frequent (30-79%)HP:0002019
Small cell lung carcinoma
Frequent (30-79%)HP:0030357
Decreased sweating
Occasional (5-29%)HP:0000966
Keratitis sicca
Occasional (5-29%)HP:0001097
Orthostatic hypotension due to autonomic dysfunction
Occasional (5-29%)HP:0004926

Quick Facts

SNOMED CT
56989000
UMLS CUI
C0022972
Fully Specified Name
Eaton-Lambert syndrome (disorder)
Specialists
0
Diagnostic Biomarkers
0
HPO Phenotypes
16
Known Treatments
4
Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.