Substance / Medication

Doxepin

Overview

Active Ingredient
doxepin
RxNorm CUI
3638

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

48 trials linked to this intervention

48
Total Trials
5
Recruiting
17
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Doxepin for insomnia: a systematic review of randomized placebo-controlled trials.
Yeung Wing-Fai, Chung Ka-Fai, Yung Kam-Ping et al. · Sleep Med Rev · 2015
PMID: 25047681Meta-Analysis
The effect of doxepin 3 mg on sleep latency: a pooled analysis of two phase 3 trials.
Fisher Matt, Araga Mako, Franks Billy et al. · Sleep Breath · 2025
PMID: 40229607RCTFull text (PMC)
Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder.
Yu Zhenghe, Han Li, Yan Pan et al. · Sleep Breath · 2024
PMID: 38123719RCT
A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial.
Samiraninezhad Nazafarin, Rezaee Mostafa, Gholami Ahmad et al. · Inflammopharmacology · 2023
PMID: 37668810RCT
Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before-after study.
Zhang Mengqi, Huang Fengmin, Jiang Feiyu et al. · Medicine (Baltimore) · 2022
PMID: 36281170RCTFull text (PMC)
Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial.
Haber Roger, Bachour Julien, Salloum Antoine et al. · Dermatol Ther · 2020
PMID: 33176043RCT
Protective effects of doxepin cream on radiation dermatitis in breast cancer: A single arm double-blind randomized clinical trial.
Shariati Laleh, Amouheidari Alireza, Naji Esfahani Hajar et al. · Br J Clin Pharmacol · 2020
PMID: 32040868RCTFull text (PMC)
Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.
Rios Romenets S, Creti L, Fichten C et al. · Parkinsonism Relat Disord · 2013
PMID: 23561946RCT
Efficacy and safety of doxepin 6 mg in a four-week outpatient trial of elderly adults with chronic primary insomnia.
Lankford Alan, Rogowski Roberta, Essink Beal et al. · Sleep Med · 2012
PMID: 22197474RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Doxepin (substance)
SNOMED CT
372587005
UMLS CUI
C0013085
RxNorm CUI
3638

Clinical Data

This intervention maps to 18 entities in the Healos knowledge graph.

5
Conditions
6
Biomarkers
4
Specialists
0
Symptoms
48
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.