Substance / Medication

Estradiol cypionate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Hypogonadism

Primary ovarian failure

Neoplasm of prostate

Neoplasm of breast

Menopausal flushing

Premature ovarian failure

Climacteric flushing

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Thyrotropin

LOINC 3016-3

secondary

Estradiol

LOINC 2243-4

primary

Testosterone

LOINC 2986-8

primary

Clinical Trials

78 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

TRADE-Testosterone Replacement and Dutasteride Effectiveness

NCT00194675Phase 4Completed53 enrolled

Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function

NCT00195520Phase 4Completed100 enrolled

Efficacy and Safety Study in Postmenopausal Women to Determine the Lowest Effective Dose for Relief of Moderate to Severe Hot-Flushes

NCT00206622Phase 4Completed425 enrolled

Study of Paxil Use in Menopausal Women

NCT00225914Phase 4Completed64 enrolled

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

NCT00227942Phase 4Completed86 enrolled

View all 78 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Impact of estradiol cypionate prior to TAI and progesterone supplementation at initial diestrus on ovarian and fertility responses in beef cows.

Martins T, Talamoni J P, Sponchiado M et al. · Theriogenology · 2017

PMID: 28846912RCT

Progesterone-based fixed-time artificial insemination protocols for dairy cows: Gonadotropin-releasing hormone versus estradiol benzoate at initiation and estradiol cypionate versus estradiol benzoate at the end.

Melo L F, Monteiro P L J, Surjus R S et al. · J Dairy Sci · 2016

PMID: 27568044RCT

Effect of estradiol cypionate and amount of progesterone in the intravaginal device on synchronization of estrus, ovulation and on pregnancy rate in beef cows treated with FTAI based protocols.

Uslenghi Gastón, Chaves Santiago González, Cabodevila Jorge et al. · Anim Reprod Sci · 2014

PMID: 24461580RCT

Time and incidence of ovulation and conception rates after incorporating estradiol cypionate into a timed artificial insemination protocol.

Sellars C B, Dalton J C, Manzo R et al. · J Dairy Sci · 2006

PMID: 16428631RCT

Optimizing timed AI protocols for Angus beef heifers: Comparison of induction of synchronized ovulation with estradiol cypionate or GnRH.

Silva Eduardo P, Wiltbank Milo C, Machado Amanda B et al. · Theriogenology · 2018

PMID: 30125829Observational

Comparative pharmacokinetics and pharmacodynamics after subcutaneous and intramuscular administration of medroxyprogesterone acetate (25 mg) and estradiol cypionate (5 mg).

Sierra-Ramírez José Alfredo, Lara-Ricalde Roger, Lujan Miguel et al. · Contraception · 2011

PMID: 22078184Observational

Use of estradiol cypionate as a substitute for GnRH in protocols for synchronizing ovulation in dairy cattle.

Stevenson J S, Tiffany S M, Lucy M C · J Dairy Sci · 2004

PMID: 15377609Observational

Comparison of ceftiofur hydrochloride and estradiol cypionate for metritis prevention and reproductive performance in dairy cows affected with retained fetal membranes.

Risco C A, Hernandez J · Theriogenology · 2003

PMID: 12620579Observational

Use of estradiol cypionate in a presynchronized timed artificial insemination program for lactating dairy cattle.

Pancarci S M, Jordan E R, Risco C A et al. · J Dairy Sci · 2002

PMID: 11860104Observational

Plasma Estradiol and Endometrial Edema Profile in Acyclic Mares After Single Administration of 17-β Estradiol, Estradiol Benzoate and Estradiol Cypionate.

Barbosa Laís Andrade, Maran Arthur Pelegi, de Almeida Maria Eduarda Rodrigues et al. · Reprod Domest Anim · 2025

PMID: 40760876PreclinicalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

Urology

Health Goals

Goals connected through associated conditions

Balance Hormones

Quick Facts

Type: Substance / Medication
Fully Specified Name: Estradiol cypionate (substance)
SNOMED CT: 109028003
UMLS CUI: C0059610

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.